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Suprep Bowel Preparation

Follow our expert guide on using Suprep for a complete colon cleanse before an afternoon colonoscopy. Get step-by-step instructions for best results!

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Texas Medical Board
Harris County Medical Society
American College of Gastroenterology
American Society for Gastrointestinal Endoscopy
Memorial hermann
Houston Methodist leading Medicine
HCA Houston Healthcare

Video Instructions

Written Instructions

General Instructions

2 Weeks Before the Procedure

Foods No change
Liquids Drink plenty of water
Medications Hold - GLP1 Agonist Medication:
  • Dulaglutide (Trulicity)
  • Exenatide (Byetta)
  • Exenatide Extended Release (Bydureon BCise)
  • Liraglutide (Victoza)
  • Lixisenatide (Adlyxin)
  • Semaglutide (Ozempic, Wegovy, Rybelsus)
  • Tirzepatide (Mounjaro)

1 Week Before the Procedure

Foods

No Nuts or Seeds - berries, cashews, corn nuts, peanuts, pecans, popcorn, walnuts

Low Fiber Diet

  • Foods - white bread, cheese, eggs, yogurt
  • Soups - clear vegetable, chicken or beef broth
  • Vegetables - cooked without skin like mashed potatoes
  • Fruits - pureed fruits without skin like applesauce
Liquids Drink plenty of water
Medications
  • Take as usual unless otherwise instructed
  • Hold - Anti-Diarrheal Medication - Imodium, Kaopectate, Pepto-Bismol
  • Hold - Iron Tablets
  • Hold - Multivitamins

Pharmacy

  • Fill or buy preparation medication
  • Pick up 3 days before your procedure

1 Day Before the Procedure

Foods
  • Clear Liquid Diet
  • Soups - clear vegetable, chicken or beef broth
  • Juices - clear only without pulp
Liquids
  • Drink plenty of water
  • No alcohol
  • No red or purple colored drinks
Medications
  • Hold - Oral Diabetes Medication
  • Insulin - Take ½ the dose the entire day
  • Blood Pressure Medication - The pre-anesthesia team (PAT) will instruct you on how to take your blood pressure medications.
  • All other medications - continue as normal

Procedure Day

Foods No food or liquids the day of the procedure

Medication Instructions

Attention

Expected Symptoms Do not stop the bowel preparation
  • Abdominal Pain
  • Bloating
  • Cramps
  • Diarrhea
  • Gas
  • Nausea

First Dosage → 10PM - 11:30PM

Step 1 10PM - 10:30PM
  • Mix first 6 ounce bottle of Suprep & 10 ounces of water into the provided container
  • Drink 16 ounces of solution
Step 2 10:30PM - 11PM

Drink 16 ounces of solution

Step 3 11PM - 11:30PM

Drink 16 ounces of water

Second Dosage → 4AM - 5:30AM

Step 1 4AM - 4:30AM
  • Mix second 6 ounce bottle of Suprep &; 10 ounces of water into the provided container
  • Drink 16 ounces of solution
Step 2 4:30AM - 5AM

Drink 16 ounces of water

Step 3 5AM - 5:30AM

Drink 16 ounces of water

12AM

Foods No food or liquids after midnight except prep solution

Frequently Asked Questions

What to expect after taking Suprep bowel prep?

Expect frequent, urgent bowel movements within 30 minutes to 3 hours. You may experience bloating, cramping, nausea, or chills. Stay hydrated and near a bathroom until the stool is clear.

Is a second bottle of Suprep necessary?

Yes, the second dose is essential for complete colon cleansing. Skipping it may leave residue in the colon, affecting the accuracy of the colonoscopy results. Follow your doctor's instructions.

Why drink water with Suprep?

Drinking water helps prevent dehydration, reduces nausea, and improves bowel cleansing. It also helps flush out remaining stool for a clearer colonoscopy view.

What time to start Suprep?

The first dose is usually taken the evening before the procedure, around 10PM - 11:30PM. The second dose is taken 4AM - 5:30AM before the colonoscopy, typically early in the morning.

What happens if you don't poop after Suprep?

If no bowel movement occurs within 6 hours, drink more clear liquids and walk around. If constipation persists, contact your doctor, as another laxative may be needed.

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